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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/s10304-003-0048-z

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1573-2568

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Molecular Mechanisms Elucidating Why Old Stomach I

Authors: Hua Hong EunHee Kim Ho Jae Lee Yoon Jae Kim Jong Joon Lee Ki Baik Hahm
Publish Date: 2012/07/29
Volume: 58, Issue: 1, Pages: 61-71
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Abstract

Detailed underlying changes have never been explored to explain how old stomach is more susceptible to nonsteroidal antiinflammatory drugs NSAIDsinduced gastric damage than young stomach although presumptively speculated as weakened mucosal defense system as well as attenuated regenerating capacity in old stomachIn spite of the same oral administration of indomethacin 01 mg indomethacin dissolved in 1 ml carboxyl methylcellulose irrespective of body weights of rat gastric mucosal damages were significantly increased in the older rats compared to the younger rats p  005 Before indomethacin administration inflammatory mediators including cytokines chemokines proteases and adhesion molecules were significantly increased in old stomach and these differences were further increased after indomethacin administration p  005 Furthermore the levels of total oxidants and apoptotic executors were significantly increased in old stomach whereas lipoxin A4 and antiapoptotic proteins such as survivin and Bcl2 were significantly decreased Increased NFκBDNA binding activity as well as the activation of JNK and p38 was responsible for the increased expressions of inflammatory mediators as well as oxidants

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