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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1002/cber.19160490102

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1573-2568

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Lower Serum Level of Adiponectin Is Associated wit

Authors: Shunsuke Yamamoto Kenji Watabe Shusaku Tsutsui Shinichi Kiso Toshimitsu Hamasaki Motohiko Kato Yoshihiro Kamada Yuichi Yoshida Shinji Kihara Miyuki Umeda Aiko Furubayashi Kazuo Kinoshita Osamu Kishida Takashi Fujimoto Akira Yamada Yoshifumi Tsukamoto Norio Hayashi Yuji Matsuzawa
Publish Date: 2011/03/30
Volume: 56, Issue: 8, Pages: 2354-2360
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Abstract

Obesity is recently known as a risk factor for endoscopic gastritis Adiponectin is an antiinflammatory cytokine secreted from fat tissue and its serum concentrations are reduced in obesity The relation between adiponectin and gastritis remains unclearWe analyzed medical records of participants of a routine health checkup examination Association among endoscopic findings serum adiponectin level and other clinical factors including age sex alcohol habit smoking habit body mass index BMI blood pressure cholesterol triglyceride glucose and insulin were investigated Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus’ suckersA total of 2400 participants were enrolled BMI was significantly higher in gastritispositive participants than in gastritisnegative participants Serum adiponectin levels were significantly lower in gastritispositive participants than in gastritisnegative participants Multivariate logistic regression analysis revealed that lower serum adiponectin level OR 096 95 CI 093–099 smoking OR 050 95 CI 030–080 higher blood pressure OR 102 95 CI 101–103 and duodenitis OR 18 95 CI 100–309 were significantly associated with endoscopic erosive gastritis

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