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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/s11075-014-9842-z

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1573-2568

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Correlations of Creactive Protein Levels and Eryt

Authors: Jin Young Yoon Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Jae Hee Cheon
Publish Date: 2013/12/19
Volume: 59, Issue: 4, Pages: 829-837
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Abstract

Accurate assessment of endoscopic severity is essential to the early detection of relapses and treatment of patients with ulcerative colitis UC However the relationships between noninvasive biomarkers and invasive endoscopic severity indices remain poorly understoodA total of 722 endoscopies in 552 patients were evaluated in this study Endoscopic activity was assessed using five widely used endoscopic scoring systems the PowellTuck assessment Mayo Endoscopic Score modified Baron Score Rachmilewitz Endoscopic Activity Index and Hanauer’s Sigmoidoscopic Index These five indices were compared with two noninvasive biomarkers erythrocyte sedimentation rate ESR and Creactive protein CRP levelsThe Pearson’s correlation coefficients of CRP and ESR with endoscopic indices were r = 0457 and 0342 in the PowellTuck assessment r = 0503 and r = 0402 in the Mayo Endoscopic Score r = 0507 and 0408 in Hanauer’s Sigmoidoscopic Index r = 0520 and 0433 in the modified Baron Score and r = 0523 and 0435 in the Rachmilewitz Endoscopic Activity Index Sensitivity and specificity ranges for CRP and ESR were 505–533  and 687–713  and 851–872  and 634–664  respectively for the detection of endoscopic remission using the five endoscopic indices

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