Authors: Yasushi Tamura Masato Igarashi Takeshi Suda Toshifumi Wakai Yoshio Shirai Takeji Umemura Eiji Tanaka Satoru Kakizaki Hitoshi Takagi Yoichi Hiasa Morikazu Onji Yutaka Aoyagi
Publish Date: 2009/09/03
Volume: 55, Issue: 7, Pages: 2095-2101
Abstract
A total of 477 HCC patients who underwent percutaneous ablative therapy or hepatectomy were enrolled Overall survival and recurrencefree survival were respectively evaluated retrospectively and prospectively Multivariate analyses of clinical prognostic factors were performed by Cox’s stepwise proportional hazard modelAFPL3 status was a statistically significant independent prognostic factor of longterm survival P = 0013 and recurrencefree survival P = 0006 in patients who underwent percutaneous ablative therapy In contrast AFPL3 did not affect prognosis in patients who underwent hepatectomyAFPL3 had different impacts on prognosis in patients with HCC who underwent percutaneous ablative therapy and hepatectomy Our results suggest that AFPL3 positivity ≥15 might be a promising indicator for choosing therapeutic modalities in HCC patients
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