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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Springer Vienna

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DOI

10.1007/bf03157321

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ISSN

1432-8798

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Genotypic and phenotypic characterization of human

Authors: Celina Monteiro Abreu Patrícia A Brindeiro Angélica N Martins Mônica B Arruda Emilio Bule Sergio Stakteas Amilcar Tanuri Rodrigo de Moraes Brindeiro
Publish Date: 2008/10/07
Volume: 153, Issue: 11, Pages: 2013-2017
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Abstract

This work evaluated HIV1 subtypes from different geographic regions and phenotypic data from drugnaïve HIVpositive pregnant women from Mozambique We analyzed 75 pol sequences from patients and the distribution of the subtypes in three regions of Mozambique and found that the majority of samples analyzed clustered with subtype C In the northern region multiple variants were found 5 ~18 subtype A 3 ~11 subtype D and 2 ~71 mosaics A/C/D and C/D whereas 18 643 isolates were subtype C from a total of 28 samples Already in the southern region only one 5 isolate of 20 samples was subtype D and the other 19 95 isolates were subtype C All 27 100 isolates from the central region grouped within clade C No primary resistance mutations to IP NNRTI or NRTI were found There was no evidence of phenotypic resistance in any of the isolates tested suggesting that neither the polymorphism in the protease nor the one found at codon 215 of the RT gene caused an increase in phenotypic resistance This finding suggests that HAART regimens indicated by WHO will probably be successful in MozambiqueThis work was supported by CNPq PROAFRICA Proc 491367/20058 with Federal University of Rio de Janeiro Rio de Janeiro Brazil We are thankful to Dr Alfredo Vergara CDC Mozambique Global AIDS Program for the helpful discussion of the data presented here

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