Authors: C E Bolt J A Davies S Randall G R B Skinner
Publish Date: 2014/04/07
Volume: 143, Issue: 3, Pages: 549-556
Abstract
The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundredfold when the virus suspension and antiserum were each diluted to one hundredfold in water instead of phosphate buffered saline This phenomenon which was observed for two human positive sera and a rabbit purified polyclonal antibody may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilutionfast’ under physiological conditions of transudation or pathological conditions of inflammation
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