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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Publisher

Springer Vienna

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DOI

10.1006/bbrc.1997.7385

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ISSN

1432-8798

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Hydroxyurea as an inhibitor of hepatitis C virus R

Authors: Akito Nozaki Manabu Morimoto Masaaki Kondo Takashi Oshima Kazushi Numata Shin Fujisawa Takeshi Kaneko Eiji Miyajima Satoshi Morita Kyoko Mori Masanori Ikeda Nobuyuki Kato Katsuaki Tanaka
Publish Date: 2010/03/05
Volume: 155, Issue: 4, Pages: 601-605
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Abstract

Hepatitis C virus HCV is the main causative agent of chronic liver disease which may develop into liver cirrhosis and hepatocellular carcinoma By using a recently developed reporter assay system in which genomelength HCV RNA replicates efficiently we found that hydroxyurea HU a DNA synthesis inhibitor inhibited HCV RNA replication Moreover we demonstrated that the antiHCV activity of the combination of IFNalpha and HU was higher than that of IFNalpha alone These results suggest that HU may be an effective antiHCV reagent that can be used not only singly but also in combination with IFNalpha to treat chronic hepatitis C

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Other Papers In This Journal:
  1. Taxonomy of prokaryotic viruses: update from the ICTV bacterial and archaeal viruses subcommittee
  2. Complete genomic sequence of a Tobacco rattle virus isolate from Michigan-grown potatoes
  3. High-temperature-mediated spontaneous mutations in the coat protein of cucumber mosaic virus in Nicotiana tabacum
  4. Engineered retroviral virus-like particles for receptor targeting
  5. Complete nucleotide sequence of rose yellow vein virus, a member of the family Caulimoviridae having a novel genome organization
  6. Capulavirus and Grablovirus : two new genera in the family Geminiviridae
  7. Immunoelectron microscopy analysis of HCMV gpUL73 (gN) localization
  8. Infectious bursal disease virus polyprotein expression arrests growth and mitogenic stimulation of B lymphocytes
  9. Association of lipid profile alterations with severe forms of dengue in humans
  10. Molecular detection and genome characterization of porcine circovirus type 2 in rats captured on commercial swine farms
  11. Sequence analysis of the CXCR4 gene derived from cells surviving feline lentivirus infection
  12. Expression of porcine Mx1 with FMDV IRES enhances the antiviral activity against foot-and-mouth disease virus in PK-15 cells
  13. Identification of amino acid residues of Ljungan virus VP0 and VP1 associated with cytolytic replication in cultured cells
  14. Comparison of the coat protein genes of Lettuce big - vein associated virus isolates from Australia with those of isolates from other continents
  15. Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro
  16. Isolation of a cytopathogenic virus from a case of porcine reproductive and respiratory syndrome (PRRS) and its characterization as parainfluenza virus type 2
  17. Eukaryotic elongation factor 1-beta interacts with the 5′ untranslated region of the M gene of Nipah virus to promote mRNA translation
  18. An overview of infectious bursal disease
  19. Understanding internalization of rotavirus VP6 nanotubes by cells: towards a recombinant vaccine
  20. Molecular characterisation of wild-type G1P[8] and G3P[8] rotaviruses isolated in Vietnam 2008 during a vaccine trial
  21. Occurrence and genetic diversity of human cosavirus in influent and effluent of wastewater treatment plants in Arizona, United States
  22. Regulation of the Borna disease virus polymerase complex by the viral nucleoprotein p38 isoform
  23. Yellow tailflower mild mottle virus: a new tobamovirus described from Anthocercis littorea ( Solanaceae ) in Western Australia
  24. Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency
  25. Evaluation of a smartphone-based rapid fluorescent diagnostic system for H9N2 virus in specific-pathogen-free chickens
  26. Noroviruses and sapoviruses in pigs in Belgium
  27. Profile of drug resistance mutations among HIV-1-infected Tunisian subjects failing antiretroviral therapy
  28. Complete genome sequence analysis of Japanese encephalitis virus isolated from a horse in India
  29. Mixed infection by two West African tomato-infecting begomoviruses and ageratum leaf curl Cameroon betasatellite in tomato in Cameroon
  30. Characteristics of two highly pathogenic avian influenza H5N8 viruses with different pathogenicity in mice
  31. Molecular characterization of a canine coronavirus NA/09 strain detected in a dog’s organs
  32. Molecular characterization of allium virus X, a new potexvirus in the family Alphaflexiviridae , infecting ornamental allium
  33. Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability
  34. Novel peptides that inhibit the propagation of Newcastle disease virus
  35. Identification of a gammaherpesvirus belonging to the malignant catarrhal fever group of viruses in Pyrenean chamois ( Rupicapra p. pyrenaica )
  36. Modulation of proinflammatory NF-κB signaling by ectromelia virus in RAW 264.7 murine macrophages
  37. Molecular characterization of a rabies virus isolate from a rabid dog in Hanzhong District, Shaanxi Province, China
  38. Sequence analysis of porcine reproductive and respiratory syndrome virus of the American type collected from Danish swine herds
  39. Deglycosylation of the NS1 protein of dengue 2 virus, strain 16681: Construction and characterization of mutant viruses
  40. Complete sequencing and phylogenetic analysis of porcine kobuvirus in domestic pigs in Northwest China
  41. Molecular detection of genotype 3 porcine hepatitis E virus in aborted fetuses and their sows
  42. Complete nucleotide sequence and genome structure of a Japanese isolate of hibiscus latent Fort Pierce virus, a unique tobamovirus that contains an internal poly(A) region in its 3′ end
  43. Evaluation of single and dual siRNAs targeting rabies virus glycoprotein and nucleoprotein genes for inhibition of virus multiplication in vitro
  44. Identification of a novel mycovirus isolated from Rhizoctonia solani (AG 2-2 IV) provides further information about genome plasticity within the order Tymovirales
  45. Novel seadornavirus (family Reoviridae ) related to Banna virus in Europe
  46. Development and evaluation of a recombinant-glycoprotein-based latex agglutination test for rabies virus antibody assessment
  47. The influence of the milieu on the rate of neutralisation of herpes simplex virus 1
  48. Dimerisation of glycoprotein E rns of classical swine fever virus is not essential for viral replication and infection
  49. An investigation into the use of human papillomavirus type 16 virus-like particles as a delivery vector system for foreign proteins: N- and C-terminal fusion of GFP to the L1 and L2 capsid proteins
  50. Neutralization of animal virus infectivity by antibody
  51. Peanut stunt virus 2b cistron plays a role in viral local and systemic accumulation and virulence in Nicotiana benthamiana
  52. Antiviral activity of recombinant porcine surfactant protein A against porcine reproductive and respiratory syndrome virus in vitro
  53. Molecular diversity of tobacco vein banding mosaic virus
  54. Genetic variation in potato virus M isolates infecting pepino ( Solanum muricatum ) in China
  55. Pregnancy outcome and clinical status of gilts following experimental infection by H1N2, H3N2 and H1N1pdm09 influenza A viruses during the last month of gestation
  56. Identification of bacteriophage types and their carriage in Staphylococcus aureus
  57. CPm gene diversity in field isolates of Citrus tristeza virus from Colombia
  58. Primary mouse dermal fibroblast cell cultures as an in vitro model system for the differential pathogenicity of cross-species herpesvirus papio 2 infections
  59. Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
  60. Full-length genome sequence analysis of a Hungarian porcine reproductive and respiratory syndrome virus isolated from a pig with severe respiratory disease
  61. Molecular characterization of a Hungarian isolate of Tobacco necrosis virus A
  62. Priming with two DNA vaccines expressing hepatitis C virus NS3 protein targeting dendritic cells elicits superior heterologous protective potential in mice
  63. No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents
  64. Biological and molecular variability among geographically diverse isolates of sweet potato virus 2
  65. Experimental inoculation of adult dairy cows with bovine coronavirus and detection of coronavirus in feces by RT-PCR
  66. Identification of novel double-stranded RNA mycoviruses of Fusarium virguliforme and evidence of their effects on virulence
  67. Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens
  68. Molecular variability analysis of five new complete cacao swollen shoot virus genomic sequences
  69. Influenza virus A(H1N1)pdm09 hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season
  70. Complete genome sequence of bellflower vein chlorosis virus, a novel putative member of the genus Waikavirus
  71. First molecular detection and characterization of Akabane virus in small ruminants in Turkey
  72. Complete genome sequence of a Tobacco necrosis virus D isolate from olive trees
  73. Structure of the immediate early gene of canine herpesvirus
  74. Genotypic and phenotypic characterization of human immunodeficiency virus type 1 isolates circulating in pregnant women from Mozambique
  75. PrP genotype frequencies of the most dominant sheep breed in a country free from scrapie
  76. Selection and characterization of an acid-resistant mutant of serotype O foot-and-mouth disease virus
  77. Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific
  78. Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa
  79. Characterization and identification of Oya virus, a Simbu serogroup virus of the genus Bunyavirus , isolated from a pig suspected of Nipah virus infection
  80. Recently agreed changes to the International Code of Virus Classification and Nomenclature
  81. Expression of the Cydia pomonella granulovirus iap3 gene
  82. Baculovirus replication induces the expression of heat shock proteins in vivo and in vitro
  83. Identification and characterization of two antisense transcripts from the major immediate early region of rat cytomegalovirus
  84. Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV
  85. Complete genome sequence of Menghai flavivirus, a novel insect-specific flavivirus from China
  86. Host range and genetic diversity of croton yellow vein mosaic virus, a weed-infecting monopartite begomovirus causing leaf curl disease in tomato
  87. Detection and characterization of a new betasatellite: variation in disease symptoms of tomato leaf curl Pakistan virus-India due to associated betasatellite
  88. Expression and interaction of the hepatitis C virus structural proteins and the 5′ untranslated regionin baculovirus infected cells
  89. Differential expression of the immediate-early 2 and 3 proteins in developing mouse brains infected with murine cytomegalovirus
  90. Indian citrus ringspot virus: a proposed new species with some affinities to potex-, carla-, fovea- and allexiviruses
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