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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Springer-Verlag

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DOI

10.1016/0921-4534(94)92178-4

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1432-8798

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Experimental infection of pigs with the newly iden

Authors: XJ Meng P G Halbur J S Haynes T S Tsareva J D Bruna R L Royer R H Purcell S U Emerson
Publish Date: 2014/04/07
Volume: 143, Issue: 7, Pages: 1405-1415
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Abstract

A novel virus of pigs swine hepatitis E virus swine HEV was recently identified and shown to be antigenically and genetically related to human HEV In the present study we attempted to infect specificpathogenfree SPF pigs experimentally with swine HEV or with human strains of HEV Serum samples collected from naturally infected pigs were used as the source of swine HEV Pigs inoculated intravenously with serum samples containing swine HEV seroconverted to antiHEV 4 to 8 weeks postinoculation and the virus spread to an uninoculated pig Swine HEV was detected in nasal and rectal swab materials as early as 2 weeks postinoculation and for 4 to 8 weeks thereafter Viremia appeared 4 to 6 weeks postinoculation and lasted 1 to 3 weeks The inoculated pigs appeared clinically normal and serum liver enzymes were not significantly elevated In contrast pigs were not infected when inoculated intravenously with about 105 monkey infectious doses of one of two human strains of HEV Sar55 or Mex14

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