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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Springer-Verlag

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DOI

10.1002/masy.19950940110

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1432-8798

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Mapping the genetic determinants of human immunode

Authors: M Kawamura R Shimano T Ogasawara R Inubushi K Amano H Akari A Adachi
Publish Date: 2014/04/07
Volume: 143, Issue: 3, Pages: 513-521
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Abstract

Two distinct infectious molecular clones of human immunodeficiency type 2 HIV2 were analyzed for their biological properties in six cell lines Fourteen chimeric and ten mutant viruses were constructed from these two viral genomes to localize the genetic determinants responsible for the phenotypes Growth property of the viruses in the cell lines together with the biochemical data showed that a major determinant for the viral tropism resides in the env gene In addition in some cell lines the accessory genes vif and nef affected the efficiency of virus replication Thus like HIV1 mutations in the auxiliary and env genes of HIV2 contributed much to the differences in virological characteristics

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  15. Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro
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  17. Eukaryotic elongation factor 1-beta interacts with the 5′ untranslated region of the M gene of Nipah virus to promote mRNA translation
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