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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Publisher

Springer Vienna

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DOI

10.1007/bf02518477

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ISSN

1432-8798

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Fulllength genome sequence analysis of a Hungaria

Authors: Ádám Bálint Gyula Balka Péter Horváth Sándor Kecskeméti Ádám Dán Attila Farsang Levente Szeredi Krisztián Bányai Dániel Bartha Ferenc Olasz Sándor Belák Zoltán Zádori
Publish Date: 2014/11/02
Volume: 160, Issue: 2, Pages: 417-422
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Abstract

Here we report the isolation of a type 1 porcine reproductive and respiratory syndrome virus PRRSV strain from a clinical outbreak of severe respiratory problems and high fever Nextgeneration sequencing was used to determine the complete genome sequence of the isolate 9625/2012 The virus belongs to a new branch within subtype 1 clade D and shows the highest similarity to PRRSV Olot/1991 and to the Amervac vaccine strain Mutation analysis of 9625/2012 revealed no evidence of recombination but did show a high proportion of amino acid substitutions in the putative neutralizing epitopes suggesting an important role of selective immune pressure in the evolution of PRRSV 9625/2012

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