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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Springer Vienna

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DOI

10.1007/s100249910001

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ISSN

1432-8798

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Inhibition of hepatitis E virus replication by pro

Authors: Lei Xu Xinying Zhou Maikel P Peppelenbosch Qiuwei Pan
Publish Date: 2014/12/05
Volume: 160, Issue: 2, Pages: 435-439
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Abstract

The ubiquitin proteasome system plays important role in virus infection A previous study showed that the proteasome inhibitor MG132 could potentially affect hepatitis E virus HEV replication In this study we found that MG132 could inhibit HEV and hepatitis C virus HCV replicationrelated luciferase activity in subgenomic models Furthermore treatment with MG132 in a HEV infectious model resulted in a dramatic reduction in the intracellular level of HEV RNA Surprisingly MG132 concurrently inhibited the expression of a luciferase gene used as a control as well as a wide range of host genes Consistently the total cellular RNA and protein content was concurrently reduced by MG132 treatment suggesting a nonspecific antiviral effect

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