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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Springer Vienna

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DOI

10.1016/j.amc.2011.05.024

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ISSN

1432-8798

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Association of lipid profile alterations with seve

Authors: Anyelo Durán Rafaela Carrero Belkis Parra Andrea González Lineth Delgado Jesús Mosquera Nereida Valero
Publish Date: 2015/05/05
Volume: 160, Issue: 7, Pages: 1687-1692
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Abstract

Previous studies have shown a relationship between circulating lipids and dengue virus infection however the association of altered lipid profiles with severe dengue remains little studied The aim of this study was to determine the association between circulating lipid content and severe dengue and/or platelet counts Ninetyeight patients 2–66 years old classified as having dengue without warning signs DNWS dengue with warning signs DWWS or severe dengue SD and 62 healthy individuals were studied Blood samples were tested for NS1 antidengue IgM platelet content total cholesterol TC triglycerides T highdensity lipoproteins HDL lowdensity lipoproteins LDL and verylowdensity lipoproteins VLDL Lipid alterations were observed mainly in patients with SD Increased T and VLDL was observed in SD and increased HDL was observed in DWWS and SD Decreased TC was found in all forms of dengue and the lowest LDL values were found in SD Platelet counts were significantly decreased in DWWS and SD when compare to DNWS A positive correlation p = 0019 between LDL values and platelet counts and a negative correlation p = 00162 between VLDL values and platelet counts were found Lipid profile alterations were associated with severe dengueThis work was supported by Instituto de Investigaciones Clínicas “Dr Américo Negrette” Facultad de Medicina Universidad del Zulia Maracaibo Venezuela and Consejo de Desarrollo Científico Humanístico y Tecnológico de la Universidad del Zulia CONDES/LUZ VACCONDESCC037914

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