Authors: Tadafumi S Tochikura Kinjiro Morimoto
Publish Date: 2013/12/27
Volume: 159, Issue: 6, Pages: 1511-1513
Abstract
The feline 3201S cell line was established from cells that survived productive infection with feline immunodeficiency virus FIV We have recently shown that 3201S cells are free of FIV DNA and are refractory to FIV reinfection In addition while the cells express CXCR4 a coreceptor for FIV infection they are unresponsive to the CXCR4 ligand In the present study we show that 3201S cells encode distinct mutations in the CXCR4 gene It appears that 3201 cells are heterogeneous consisting of phenotypically diverse mixed populations resulting from genetic mutations suggesting that this defect can render the CXCR4 receptor expressed in 3201S cells biologically dysfunctionalWe are grateful to Dr Lawrence E Mathes for providing the 3201 cell line We also wish to thank Dr Nobuyuki Itoh and Dr Hideo Saji for their constant support and encouragement and Dr Nancy Long Sieber for critically reviewing the manuscript and helpful discussions
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