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Title of Journal: Arch Virol

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Abbravation: Archives of Virology

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Springer Vienna

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DOI

10.1016/j.amjcard.2006.01.041

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1432-8798

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Molecular characterization of a rabies virus isola

Authors: Jinghui Zhao Shuchao Wang Shoufeng Zhang Ye Liu Jinxia Zhang Fei Zhang Lijuan Mi Rongliang Hu
Publish Date: 2013/12/19
Volume: 159, Issue: 6, Pages: 1481-1486
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Abstract

A canine rabies virus ShaanxiHZ6 was isolated in Shaanxi Province China in 2009 Its genome has been completely sequenced and found to be closely related to the China I rabies virus strains widely circulating in China The genomic length was 11923 base pairs and the overall organization of the genome was similar to that of other rabies virus isolates Compared with isolates CQ92 and J 84 amino acid substitutions 7 in the N gene 15 in P 6 in M 25 in G 31 in L were observed in strain ShaanxiHZ6 Amino acid substitutions of R264H and V332I were noted in the G protein antigenic site I and site III respectively Residue 333 of the G protein which is considered to be associated with pathogenicity was Arg in ShaanxiHZ6 These and other substitutions may help provide an explanation why the China I lineage strain maintains its prevalence in China

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