Authors: HungChin Tsai ShengFu Liu KuanSheng Wu YungChing Liu MinHon Shi EngRin Chen ChuanMin Yen Susan ShinJung Lee YenLin Huang YaoShen Chen
Publish Date: 2008/06/15
Volume: 31, Issue: 4, Pages: 247-253
Abstract
To quantitate cerebrospinal fluid CSF concentrations of matrix metalloproteinase 9 MMP9 in adult patients with Klebsiella pneumoniae meningitis and to correlate levels of MMP9 with parameters of intrathecal inflammation and analyze the kinetic changes of MMP9 In a prospective cohort study levels of MMP9 and tissue inhibitor of matrix metalloproteinase TIMP1 concentrations were measured in the CSF of six adult patients with meningitis and 11 controls MMP9 and TIMP1 were detected in all of the six patients at presentation and follow up lumbar puncture CSF levels of MMP9 671 ± 729 ng/ml and TIMP14543 ± 2429 ng/ml were higher in patients than in the control group 007 ± 011 ng/ml and 2714 ± 3934 ng/ml respectively Levels of MMP9 correlated with CSF concentrations of protein cell count and lactate Repeated lumbar punctures showed that levels of MMP9 decrease during clinical recovery although the levels of MMP9 in the CSF are variable because of the small number of cases The relative change in gelatin zymography is comparable to the changes of MMP9 levels found in ELISA MMP9 levels in CSF may be a useful tool in followup in patients with K pneumoniae meningitisThis work is supported by the Summer Medical Student Research Program 2007 from the Medical Foundation in Memory of Dr DehLin Cheng and also supported by grant VGHKS96027 from Kaohsiung Veterans General Hospital and grant NSC962320B075B002 from the National Science Council Republic of China
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