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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1007/978-1-4757-1845-4

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1573-2576

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Effects of PPARγ Agonist Treatment on LPSInduced

Authors: Ding Mingfeng Ming Xiaodong Liu Yue Piao Taikui Xiao Lei Liu Ming
Publish Date: 2014/05/18
Volume: 37, Issue: 6, Pages: 1919-1924
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Abstract

PPARγ a member of the nuclear receptor superfamily plays an important role in lipid metabolism and inflammation The aim of this study was to investigate the preventive effects of synthetic PPARγ agonist rosiglitazone on lipopolysaccharide LPSinduced mastitis in rats The mouse model of mastitis was induced by the injection of LPS through the duct of the mammary gland Rosiglitazone was injected 1 h before the induction of LPS intraperitoneally The results showed that rosiglitazone attenuated the infiltration of inflammatory cells the activity of myeloperoxidase MPO and the production of tumor necrosis factorα TNFα interleukin6 IL6 and interleukin1β IL1β in a dosedependent manner Additionally Western blotting showed that rosiglitazone inhibited the phosphorylation of IκBα and NFκB p65 These results indicated that rosiglitazone has a protective effect on mastitis and the antiinflammatory mechanism of rosiglitazone on LPSinduced mastitis in rats may be due to its ability to inhibit NFκB signaling pathways PPARγ may be a potential therapeutic target against mastitis

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