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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1016/0041-0101(89)90008-1

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1573-2576

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The Chronicity of Tonsillitis Is Significantly Cor

Authors: Jung Hyun Chang Soochan Kim Jihye Koo Peter J L Lane Sun Och Yoon Ah Young Park KyungSu Kim MiYeon Kim
Publish Date: 2013/09/11
Volume: 37, Issue: 1, Pages: 132-141
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Abstract

The current study explored the relationship between lymphoid tissue inducer LTi cells and patients’ clinical and immunological status LTi cells are critical for lymphoid tissue development and maintenance of CD4 T celldependent immune responses The percentage of CD117+CD3−CD56−CD127+ RORγ+ LTi cells isolated from human tonsils was determined and correlated with changes in other immune subsets and clinical factors We found that the portion of LTi and CD4 T cells was significantly increased in chronic tonsillitis compared to noninflamed tonsils Additionally the expression of OX40 by memory CD4 T cells and OX40 ligand OX40L and interleukin IL22 by LTi cells was higher in chronically inflamed tonsils The treatment for tonsillitis with ibuprofen did not alter LTi cell viability and the expression of OX40L and IL22 These results demonstrate that during chronic inflammation LTi cells are increased and express higher levels of OX40L and IL22 and this is correlated with an increase in memory CD4 T cells

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