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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1002/ardp.19522850121

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1573-2576

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Effects of Emphasis Type="Italic"Canavalia/Emph

Authors: Nilson Vieira Pinto Benildo Sousa Cavada Lucas Ferreira Brito Ronniery Ilario Pereira Mayara Torquato Lima da Silva Rondinelle Ribeiro Castro Alana de Freitas Pires Ana Maria Sampaio Assreuy
Publish Date: 2013/02/03
Volume: 36, Issue: 3, Pages: 713-722
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Abstract

The antiinflammatory activity of Canavalia seed lectins Canavalia gladiata CGL Canavalia maritima ConM and Canavalia brasiliensis ConBr was evaluated by intravenous administration in rats In nonsensitized rats cellular edema elicited by carrageenan was reduced 45–51  by ConM and 44–59  by CGL Osmotic edema elicited by dextran was reduced by ConM and CGL in 27  and 29  ConM and CGL reduced the edema elicited by larginine in 53  and that of prostaglandin E2 in 48  and 36  Leukocyte migration elicited by carrageenan was reduced in 49  by ConM and in 55  by CGL attenuated in 4× by glucose and peritoneal TNFα content in 82  In rats sensitized ConM inhibited the paw edema and leukocyte migration elicited by ovalbumin in 34  and 70  ConM and CGL are antiinflammatory mainly in cellular events mediated by prostaglandin E2 nitric oxide and TNFα in nonsensitized rats However only ConM is antiinflammatory in sensitized rats CGL effect involves the lectin domainThe authors are thankful to the financial support of Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico FUNCAP and Institutos Nacionais de Ciência e Tecnologia INCT Instituto de NanoBioEstruturas Simulação NanoBioMolecular NANOBIOSIMES Cavada BS and Assreuy AMS are senior investigators of CNPq/Brazil The authors declare that there are no conflicts of interest

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