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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1016/0738-3991(94)90195-3

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1573-2576

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Attenuation of Hyperoxiainduced Lung Injury in Ra

Authors: Wei Tao YuSheng Shu QianBing Miao YaBing Zhu
Publish Date: 2011/02/08
Volume: 35, Issue: 1, Pages: 150-157
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Abstract

Oxidative stress and inflammation are involved in the pathogenesis of acute lung injury ALI Adrenomedullin AM is an endogenous peptide with antiinflammatory and antioxidant properties This study investigated that whether AM treatment may ameliorate hyperoxiainduced ALI in rats via inhibition of oxidative stress and inflammation Rats were randomized to receive continuous intravenous infusion of AM or saline through a microosmotic pump and then ALI was induced by exposing the animals in sealed cages 95 oxygen for 72 h Exposure to hyperoxia caused lung injury as increased infiltration of inflammatory cells and disruption of lung architecture AM administration markedly improved these changes Additionally AM administration significantly increased glutathione peroxidase and superoxide dismutase activities Meanwhile hyperoxiainduced increase of lipid hydroperoxide level was markedly reduced by AM treatment Moreover nuclear factorkappa BDNAbinding activity and production of the inflammatory mediators interleukin6 keratinocytederived chemokine and matrix metalloproteinase 9 were significantly inhibited by AM treatment AM ameliorates hyperoxiainduced ALI in rats by suppression of oxidative stress and inflammation

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