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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1007/s00373-006-0680-1

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1573-2576

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Association of Ang2 with Integrin β2 Controls Ang

Authors: Louise Bezuidenhout Peter Zilla Neil Davies
Publish Date: 2009/09/02
Volume: 32, Issue: 6, Pages: 393-
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Abstract

Angiopoietin2 Ang2 an angiogenic factor that is generally considered an autocrine factor for endothelial cells was shown in a previous study to upregulate peripheral blood monocyte fibrinolysis in concert with plateletderived growth factorBB PDGFBB This upregulation of fibrinolysis was demonstrated to be due to upregulation of elements of the matrix metalloproteinase and serine protease fibrinolytic pathways The manner in which Ang2 interacts with monocytes was not elucidated though no expression of the angiopoietin receptor tyrosine kinase Tie2 was found for monocytes In this study Ang2 was found to bind to integrin β2 and functional inhibition of integrin β2 eliminated Ang2/PDGFBBmediated upregulation of monocyte fibrin invasion Additionally integrin β2 blockade significantly inhibited the Ang2/PDGFBB based increase in matrix metalloproteinase9 MMP9 and membrane type1MMP MT1MMP Furthermore Ang2/PDGFBBupregulated urokinase plasminogenactivator receptor uPAR was shown to be associated in complexes with integrin β2 In addition Ang2 was shown to upregulate PDGFRβ expression in monocytes Therefore several components of the mechanism via which the novel interaction of Ang2 and PDGFBB with monocytes occurs have been identified

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