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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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10.1007/s10958-014-1747-9

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1573-2576

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Chitotriosidase Expression during MonocyteDerived

Authors: Michelino Di Rosa Daniele Tibullo Daniela Cambria Gisella Distefano Salvatore Saccone Francesco Di Raimondo Lucia Malaguarnera
Publish Date: 2015/05/31
Volume: 38, Issue: 6, Pages: 2082-2091
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Abstract

The chitotriosidase CHIT1 is a glycosyl hydrolase GH which has been found highly expressed in activated macrophages and in different monocytederived cell lines such as Kupffer cells and osteoclasts as well is differently produced in diverse stages of macrophage polarization M1 and M2 Recent finding suggests that CHIT1 plays a crucial role in innate and acquired immunity Dendritic cells DCs are a complex group of cells that play a critical role in immune response The aim of this study was to investigate the presence of CHIT1 during the differentiation and maturation of DCs Magneticallyisolated peripheral blood monocytes were differentiated toward immature DCs iDC and mature DCs mDCs Our results showed for the first time that CHIT1 is expressed during the process of differentiation and maturation of DCs in a timedependent manner We found that CHIT1 is evenly distributed in cytoplasm of both the iDCs and mDCs Additionally a significantly increased expression of CHIT1 mRNA and protein was observed in mature DCs These results suggest that CHIT1 play an important role in the DCs immunoresponse

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