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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1007/bf02921544

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1573-2576

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The Neuroprotective Effect of Glycyrrhizic Acid on

Authors: Tarık Akman Mustafa Guven Adem Bozkurt Aras Adile Ozkan Halil Murat Sen Ali Okuyucu Yildiray Kalkan Ibrahim Sehitoglu Coskun Silan Murat Cosar
Publish Date: 2015/02/17
Volume: 38, Issue: 4, Pages: 1581-1588
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Abstract

Cerebral ischemia is still one of the most important topics in neurosciences Our study aimed to investigate the neuroprotective and antioxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats Twentyfour rats were divided equally into three groups A middle cerebral artery occlusion model was performed in this study where sham and glycyrrhizic acid were administered intraperitoneally following middle cerebral artery occlusion Group I was evaluated as control Malondialdehyde MDA superoxide dismutase SOD and nuclear respiratory factor1 NRF1 levels were analyzed biochemically on the right cerebral hemisphere while ischemic histopathological studies were completed to investigate the antioxidant status Biochemical results showed that SOD and NRF1 levels were significantly increased in the glycyrrhizic acid group compared with the sham group while MDA levels were significantly decreased On histopathological examination cerebral edema vacuolization degeneration and destruction of neurons were decreased in the glycyrrhizic acid group compared with the sham group Cerebral ischemia was attenuated by glycyrrhizic acid administration These observations indicate that glycyrrhizic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress

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