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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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10.1007/s00010-010-0040-3

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1573-2576

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Pharmacological Activation of Peroxisome Prolifera

Authors: Dongsheng Mou Hua Yang Changhua Qu Juan Chen Chaogui Zhang
Publish Date: 2016/06/09
Volume: 39, Issue: 4, Pages: 1538-1546
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Abstract

Peroxisome proliferatoractivated receptors PPARs are nuclear receptors which mediate glucose and lipid homeostasis by regulating the expression of a large number of transcription factors Sphingomyelin synthase SMS is a key enzyme in the synthesis of sphingomyelin SM and its expression and activity have been reported to be associated with atherosclerosis AS Although there have been many functional PPAR and SMS studies on atherosclerosis in recent years few have investigated the correlation between the activation of PPARδ and the activity of SMS In his study macrophageinduced foam cells were utilized to model important pathological changes that occur in AS The influence of PPARδ agonism by GW501516 on SMS and its product molecule SM were measured Results indicated that the activation of PPARδ was correlated in a positive manner with the activity of SMS2 and the content of SM was dose dependently increased by GW501516 Together this study represents the first to suggest that PPARδ activation may be a potential risk of AS through enhancing activity of SMS2

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