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Title of Journal: Inflammation

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Abbravation: Inflammation

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Springer US

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DOI

10.1007/bfb0106380

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1573-2576

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Quercetin Protects Mice from ConAInduced Hepatiti

Authors: Xi Li Hongchun Liu Qunyan Yao Beili Xu Shuncai Zhang Chuantao Tu
Publish Date: 2015/08/13
Volume: 39, Issue: 1, Pages: 96-106
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Abstract

The dietary flavonoid quercetin has hepatoprotective effects We analyzed the effects of quercetin on concanavalin A ConAinduced hepatitis in mice and its underlying molecular mechanisms of action Mice were administered quercetin 50 mg/kg body weight ip or vehicle 30 min before intravenous administration of ConA Quercetin pretreatment significantly reduced the ConAinduced elevations in plasma aminotransferase concentrations and liver necrosis as well as reducing serum concentrations of the proinflammatory cytokines tumor necrosis factor TNFα interferonγ and interleukin4 Quercetin pretreatment also reduced expression of highmobility group box 1 protein HMGB1 and tolllike receptor TLR2 and TLR4 messenger RNA mRNA and protein in liver tissues Quercetin pretreatment significantly inhibited degradation of inhibitory kappa B alpha and modulated ConAinduced nuclear translocation in the liver of nuclear factor kappa B NFκB p65 These results demonstrate that quercetin protects against ConAmediated hepatitis in mice by attenuating the HMGB1–TLRs–NFκB signaling pathway

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