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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Kluwer Academic Publishers

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DOI

10.1007/s40278-014-8241-5

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1573-4978

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Helicase mystery of progression

Authors: Rajneesh Kumar Gaur
Publish Date: 2006/11/21
Volume: 34, Issue: 3, Pages: 161-164
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Abstract

Helicases mode of unwinding the nucleic acids and translocation along single stranded nucleic acids is still a subject of great curiosity Based on the energy transduction and electrophilic interactions we present a model to explain the mode of action of active helicases This model considers that both strand separation as well as translocation is active processes fueled by NTP hydrolysis The model proposes that the translocation appears to involve creeping of helicase over the ssNA lattice rather than inchworm movement

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