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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1002/asna.18821011505

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ISSN

1573-4978

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Hepatocyte growth factor protects endothelial prog

Authors: XueJun Yu MingBao Song JianFei Chen GuangXu Zhu Gang Zhao Hong Wang Lan Hunag
Publish Date: 2009/08/15
Volume: 37, Issue: 5, Pages: 2423-2429
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Abstract

Risk factors for coronary heart disease including lowdensity lipoprotein LDL cholesterol can reduce the number and activity of endothelial progenitor cells EPCs thereby hindering their usefulness for treating cardiovascular disease in transplants The aim of this study was to investigate whether hepatocyte growth factor HGF can protect EPCs from the inhibition caused by LDL cholesterol EPCs derived from mouse bone marrow were isolated and cultured in medium supplemented with different concentrations of LDL cholesterol 345dimethylthiazol2yl25diphenyltetrazolium bromide assays modified Boyden chambers and flow cytometry were used to evaluate EPC proliferation migration and apoptosis The role of Akt in this process was also evaluated through observing the expressions of total Akt and Akt phosphorylation and pharmacological analysis Our results indicate that LDL cholesterol inhibits the proliferation and migration of EPCs and induces their apoptosis However HGF improves the activity of EPCs inhibited by LDL cholesterol and it simultaneously decreases EPC apoptosis induced by LDL cholesterol Blockade of phosphoinositide3 kinase PI3K by Ly294002 attenuates the effect of HGF Furthermore our experiments suggest that HGF increases the level of phosphorylated Akt in EPCs rather than Akt However PI3K inhibitor reduces the increase of phosphorylated Akt level induced by HGF These findings suggest HGF promotes endothelial progenitor cells migration proliferation and survival impaired by lowdensity lipoprotein cholesterol via the PI3K/Akt signaling pathway

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