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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1007/s00214-009-0624-y

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ISSN

1573-4978

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Gender specificity of a genetic variant of angiote

Authors: Negar Firouzabadi Nader Tajik Ehsan Bahramali Hooman Bakhshandeh Mohsen Maadani Massoumeh Shafiei
Publish Date: 2013/05/10
Volume: 40, Issue: 8, Pages: 4959-4965
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Abstract

Etiological factors for coronary artery disease CAD involve a wide range of gene and environmental interactions One of the systems being implicated in the pathophysiology of CAD is the reninangiotensin system RAS However the genetic polymorphisms of this system have not been widely studied in Iranian patients diagnosed with CAD The aim of this study was to assess the relationship between six gene polymorphisms of RAS components and CAD in a sample of Iranian population A total of 374 participants were enrolled in a case/control study The presence of CAD was determined by coronary angiography Genotyping of six RAS gene polymorphisms was performed using a modified PCR–RFLP method Our results revealed for the first time a significant independent association of angiotensinconverting enzyme ACE A240T polymorphism and incidence of CAD among Iranian women P = 0005 OR = 204 95  CI = 249–412 There has also been a significant difference in genotype distribution of ACE A240T P = 0008 and angiotensin II receptor type 2 C3123A polymorphism P = 0032 in Iranian female participants In conclusion TT genotype of ACE A240T seems to be a genetic risk factor for CAD in Iranian women

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