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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1007/s00105-004-0873-6

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ISSN

1573-4978

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In vitro inhibition of 7ethoxyresorufinEmphasis

Authors: Liane Wagner Vladimir Zlabek Sofia Trattner Galia Zamaratskaia
Publish Date: 2012/10/12
Volume: 40, Issue: 1, Pages: 457-462
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Abstract

In the present study we investigated the effect of sesamin on CYP1A 7ethoxyresorufinOdeethylase EROD and CYP2E1like activities pnitrophenol hydroxylase PNPH in hepatic microsomes obtained from Atlantic salmon Salmo salar and common carp Cyprinus carpio Addition of sesamin to the incubations in a concentration range from 1 to 200 μM decreased the activities of EROD and PNPH in a concentration dependent manner It is likely that the inhibition of EROD was mechanismbased as demonstrated by the decrease in the IC50 value from 59 to 32 μM for A salmon and from 79 to 30 μM for common carp when 5 min preincubation step was included Similarly PNPH activity was inhibited by sesamin with a decrease in the IC50 values from 617 to 152 μM for A salmon and from 1943 to 207 μM for common carp Thus our results indicated that sesamin can act as a mechanismbased inhibitor of EROD and PNPH activity with similar degree of inhibition in both fish species More importantly the inhibition of CYP1A in addition to being mechanismbased was competitive with Ki value of 53 μM

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