Authors: HuaPin Wang ChingWen Liu HsuehWen Chang JenWei Tsai YaZhu Sung LiChing Chang
Publish Date: 2012/11/27
Volume: 40, Issue: 3, Pages: 2347-2355
Abstract
Cordyceps sinensis CS is an entomogenous fungus used as a tonic food and Chinese medicine to replenish health This study investigated the protective effects of CS in rats postrenal ischemia–reperfusion I/R sequence by analyzing the influence on stromal cellderived factor1α SDF1α and chemokine CXC motif receptor 4 CXCR4 expressions and senescence during recovery Chemokine SDF1 now called chemokine CXC motif ligand 12 CXCL12 and its receptor CXCR4 are crucial in kidney repair after ischemic acute renal failure CS treatment significantly alleviated I/Rinduced renal damage assessed by creatinine levels p 005 and abated renal tubular damages assessed by periodic acidSchiff with diastase PASD staining CS induced early SDF1α expression and increased CXCR4 expression 1–6 h postreperfusion Histology studies have revealed that CS induced SDF1α in squamous cells of Bowman’s capsule mesangial cells distal convoluted tubules DCT and proximal convoluted tubules PCT CS also improved renal repair in I/Rinduced injury by increasing Ki67 staining I/R induced renal senescence after 3 and 6 h of reperfusion However CS alleviated I/Rinduced senescence at early stage 1 and 3 h We conclude that CS protects against I/R injury via the SDF1/CXCR4signaling axis and alleviates senescence
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