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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1007/s00277-012-1670-4

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1573-4978

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Matrine inhibits the growth of retinoblastoma cell

Authors: Qingliang Shao Xiaxia Zhao Li Yao
Publish Date: 2014/02/11
Volume: 41, Issue: 5, Pages: 3475-3480
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Abstract

Matrine one of the main active components of extracts from the dry roots of Sophora flavescens has potent antitumor activity in vitro and in vivo Here we investigated the apoptosis in matrinetreated retinoblastoma cells The results showed that matrine could inhibit cell proliferation and induce apoptosis in a dose and timedependent manner Further investigation revealed that a disruption of mitochondrial transmembrane potential and an upregulation of reactive oxygen species in matrinetreated cells By western blot analysis we found that the upregulation of cleaved Apaf1 cleaved caspase3 cleaved caspase9 cleaved caspase7 Bax/Bcl2 varying with different concentration of matrine These protein interactions may play a pivotal role in the regulation of apoptosis Taken together these results overall indicate that matrine could be used as an effective antitumor agent in therapy of retinoblastoma targets the caspasedependent signaling pathway

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