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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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ISSN

1573-4978

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Tolllike receptor polymorphisms and vasculitis su

Authors: Gwan Gyu Song Sung Jae Choi Jong Dae Ji Young Ho Lee
Publish Date: 2012/10/14
Volume: 40, Issue: 2, Pages: 1315-1323
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Abstract

The aim of this study was to determine whether tolllike receptor TLR polymorphisms confers susceptibility to vasculitis A literature search was conducted using the PubMed and Embase A metaanalysis on the associations between the TLR4 Asp299Gly polymorphisms and vasculitis was carried out using allele contrast dominant and codominant models and a systematic review of other TLR polymorphisms Fourteen studies involving 2064 patients and 2481 controls were included in this systematic review which comprised nine on Behcet’s disease BD three on giant cell arteritis GCA and one on Henoch–Schenlein purpura HSP Metaanalysis of six studies showed a significant association between the Gly/Gly+Gly/Asp genotype of the TLR4 Asp299Gly polymorphism and vasculitis and GCA Odds ratio OR = 1368 95  confidence interval CI = 1300–1815 p = 0030 OR = 1523 95  CI = 1099–2112 p = 0012 Under a random effects model the adjusted ORs calculated using the trim and fill technique revealed an association between the Gly/Gly+Gly/Asp genotype of the TLR4 Asp299Gly polymorphism and vasculitis OR = 1544 95  CI = 1091–2185 p  005 Stratification by vasculitis type using the codominant model showed the trend for the association with GCA OR = 1569 95  CI = 0970–2538 p = 0066 There were three studies on the TLR2 Arg753Gln polymorphism and two on the TLR4 Thr399Ile polymorphism no association with vasculitis was evident Among the TLR2 TLR7 and TLR9 polymorphisms included in this review one Asian study revealed a significant association between the TLR7 rs5743733 and rs3853839 with BD p = 0002 0036 and one Asian study showed an association of TLR9 rs352140 with BD p = 0009 This metaanalysis demonstrates that the TLR4 Asp299Gly polymorphism may confer susceptibility to GCA The review of published data suggests that other TLR polymorphisms such as TLR7 and TLR9 may play a role in vasculitis

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