Authors: Hafedh Makni Jamel Daoud Hanène Ben Salah Nedia Mahfoudh Olfa Haddar Héla Karray Tahya Boudawara Abdelmonême Ghorbel Abdelmajid Khabir Mounir Frikha
Publish Date: 2009/08/28
Volume: 37, Issue: 5, Pages: 2533-2539
Abstract
In order to study the association of HLAA B and/or DRB1 DQB1 and the nasopharyngeal carcinoma NPC 141 patients affected with NPC were typed for the HLA class I by serology method of microlymphocytotoxicity Among these patients 101 were genotyped for HLA class II system by the PCRSSP technique HLA typing results were compared to those of 116 controls We found that the HLAA31 and A33 antigens were significantly more expressed in patients than in the controls P = 0016 and 0010 respectively and the HLAA19 antigen was significantly more frequent in patients when compared to the controls P = 0007 The HLADRB103 and DRB113 alleles were significantly more frequent in patients as compared to the controls The DRB101 allele was expressed with a frequency of 2069 in the controls whereas it was only detected in 396 of the NPC patients Furthermore the DQB105 allele was expressed at a frequency which was significantly less important in affected patient P = 003 whereas the DQB102 allele was more frequent in patients P = 0643 × 10−4 Thus our study revealed a significant increase of HLAA31 A33 A19 B16 B53 and DRB103 DRB113 and DQB102 alleles in our patients These markers could play a predisposing role in the development of NPC In contrast a decrease of HLAB14 B35 and DRB101 and DQB105 alleles was found suggesting a likely protective effect
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