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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1016/0026-2714(81)90181-5

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ISSN

1573-4978

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Involvement of βarrestins in cancer progression

Authors: Shanshan Hu Di Wang Jingjing Wu Juan Jin Wei Wei Wuyi Sun
Publish Date: 2012/10/18
Volume: 40, Issue: 2, Pages: 1065-1071
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Abstract

βarrestins including βarrestin1 and βarrestin2 are ubiquitous cytosolic proteins which localize in the cytoplasm and plasma membrane initially be regarded as an potential character in G proteincoupled receptors GPCR desensitization sequestration and internalization Besides recent many studies increasingly revealed that βarrestins served widely as versatile adapter proteins for scaffolding many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors and downstream kinases As we known the biologic and clinical behaviors of many tumors are largely determined by multiple molecular signal pathways More recently accumulating evidences established that βarrestins got widely involved in many cancer developmental signaling events which responsible for tumor viability and metastasis suggesting an impressive role of βarrestins in tumor progression Because of the regulation and biological output of βarrestins is so complex the role of βarrestins in cancer development still remains enigmatic However the further understanding with the clinical prognosis and oncogenic potential of βarrestins might facilitate the identification of diagnosis biomarkers and development of drug targets in cancer In this article we reviewed a comprehensive summary of the βarrestinsmediated functions in human cancers

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