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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1007/bf01597497

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ISSN

1573-4978

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Modulatory effect of resveratrol on Emphasis Type

Authors: Helena Schirmer Talita Carneiro Brandão Pereira Eduardo Pacheco Rico Denis Broock Rosemberg Carla Denise Bonan Maurício Reis Bogo André Arigony Souto
Publish Date: 2011/06/25
Volume: 39, Issue: 3, Pages: 3281-3289
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Abstract

Sirtuins SIRTs are NAD+dependent deacetylases that catalyze the hydrolysis of acetyllysine residues They play an important role in many physiological and pathophysiological processes such as the regulation of lifespan and the prevention of metabolic diseases In this study we analyzed the effect of resveratrol on the gene expression levels of SIRT1 SIRT3 SIRT4 PGC1α and NAMPT as well as its effect on NAD+ and NADH levels in the liver of non stressed or non impaired wildtype zebrafish Semiquantative RTPCR assays showed that resveratrol did not change the mRNA levels of SIRT1 and PGC1α but decreased the expression levels of the SIRT3 SIRT4 and NAMPT genes The decrease in NAMPT mRNA levels was accompanied by an increase in NADH levels thereby decreasing the NAD+/H ratio Taken together our results suggest that resveratrol plays a modulatory role in the transcription of the NAMPT SIRT3 and SIRT4 genes Zebrafish is an interesting tool that can be used to understand the mechanisms of SIRTs and NAMPT metabolism and to help develop therapeutic compounds However further investigations using healthy experimental animals are required to study the modulation of the SIRT and NAMPT genes by resveratrol before it is used as a nutraceutical compound in healthy humans

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