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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1016/0923-1811(93)91394-a

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ISSN

1573-4978

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Tissuespecific distribution of uncoupling protein

Authors: ChunMei Zhang Ying Gu Dani Qing Jingai Zhu Chun Zhu Min Zhang XiRong Guo
Publish Date: 2009/10/16
Volume: 37, Issue: 7, Pages: 3177-3182
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Abstract

Uncoupling proteins UCPs are a proton transporter family located in the mitochondrial inner membrane Thus far five molecules UCP1–UCP5 have been identified as members of the UCP family Recently UCPs have attracted considerable interest in research on energy metabolism and obesity However to date no study has focused on a comprehensive and systematic evaluation of the tissuespecific distribution of UCPs in obese individuals Our study presents evidence of differential tissue expression profiles of five isoforms of UCPs in normal and dietinduced obese DIO rats using realtime polymerase chain reaction PCR analysis The results clearly show that the tissuespecific expression patterns of individual isoforms between DIO and normal rats are quite distinct which suggests a close relationship between the alterations in UCP expression and dietary obesityThis study was supported by grants from the National Natural Science Foundation of China No 30772364 30801256 the Natural Science Foundation of Jiangsu Province China No BK2007230 BK2008078 and the foundation of Nanjing Medical University No 07NMUZ029

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