Authors: Gwan Gyu Song SangCheol Bae Young Ho Lee
Publish Date: 2012/10/06
Volume: 39, Issue: 12, Pages: 10739-10745
Abstract
The aim of this study was to determine whether the Glutathione Stransferase M1 GSTM1 and P1 GSTP1 polymorphisms confer susceptibility to rheumatoid arthritis RA Metaanalysis was performed on the associations between the GSTM1 and GSTP1 null genotypes and RA and on the association between smoking or seropositive status and the GSTM1 null genotype in RA patients Twelve studies involving 3990 RA patients and 2815 controls were included in the metaanalysis All 12 studies examined the GSTM1 polymorphism and three the GSTP1 polymorphism Metaanalysis of GSTM1 null polymorphism in 2291 RA and 2713 control subjects revealed no association between RA and the GSTM1 null genotype OR = 1139 95 CI = 0914–1419 p = 0246 Stratification by ethnicity indicated no association between the GSTM1 null genotype and RA in Asians or Europeans OR = 1245 95 CI = 0729–2124 p = 0422 OR = 1023 95 CI = 0794–1318 p = 0863 Furthermore there was no association between smoking and the GSTM1 null genotype OR = 0943 95 CI = 0734–1210 p = 0642 In addition no association was found between seropositive status including antiCCP anticitrullinated antibody and/or RF rheumatoid factor and the GSTM1 null genotype Metaanalysis of 915 RA and 1082 controls revealed no association between RA and the GSTP1 null genotype OR = 0965 95 CI = 0802–1161 p = 0704 Furthermore stratification by ethnicity indicated no association between the GSTP1 null genotype and RA in Europeans OR = 0794 95 CI = 0594–1061 p = 0119 This metaanalysis suggests that the GSTM1 and GSTP1 polymorphisms are not associated with the risk of RA However due to the small number of studies included and our inability to perform subgroup analysis by environmental factors further studies are required to explore the roles played by GSTM1 and GSTP1 polymorphisms in the pathogenesis of RA
Keywords: