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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1016/0022-3913(88)90058-3

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ISSN

1573-4978

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Association study of a common genetic variant in p

Authors: Hong Li Yadong Tian Guirong Sun Xiaojun Liu Ruirui Jiang Ruili Han Guoxi Li Xiangtao Kang
Publish Date: 2014/07/20
Volume: 41, Issue: 11, Pages: 7175-7181
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Abstract

Increasing reports have verified that miRNAs had an important effect on the growth and development in farm animals To evaluate the possible effect of miR1596 polymorphisms on chicken economic traits directly sequencing and polymerase chain reaction–restriction fragment length polymorphism association analysis as well as online software were used The results showed that a C  T polymorphism existed in the miR1596 gene of the Gushi × Anka F2 resource population The association analysis showed that it was significantly relevant with the potential of hydrogen of leg muscle fat content of dry sample and fat content of fresh sample shank length at 0 day and 4 weeks of age leg weight leg muscle weight and breast muscle weight P  005 and highly significant association with shank girth at 8 weeks of age and abdominal fat weight P  001 We predicted the secondary structure of Gallus gallusmiR1596 ggamiR1596 and the free energy by using Mfold which were not altered MiR1596 is conserved between chicken and turkey Our data implied that miR1596 might participate in regulating the muscle development and adipogenesis

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