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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1016/0006-8993(75)90110-9

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ISSN

1573-4978

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The mechanism of acidic hydrolysis of esters expla

Authors: Agnieszka FedorukWyszomirska Małgorzata GielPietraszuk Eliza Wyszko Maciej Szymański Jerzy Ciesiołka Mirosława Z Barciszewska Jan Barciszewski
Publish Date: 2008/09/23
Volume: 36, Issue: 7, Pages: 1647-1650
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Abstract

The hepatitis delta virus HDV ribozyme is an RNA enzyme that catalyzes the sitespecific transesterification reaction Using high hydrostatic pressure HHP technique we showed that HDV ribozyme catalyzes the reaction of RNA cleavage in the absence of magnesium ions according to mechanism of acidic hydrolysis of esters HHP induces changes of water structure lowering pH and effect ribozyme catalytic site structure formation without magnesium HHP similarly to magnesium ion at ambient pressure stabilizes the higher order RNA structure of HDV but Mg2+ is not involved in the catalysis Our results clearly support the new mechanism of HDV hydrolysis and show advantages of using HHP in analysis of macromolecules interaction

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