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Title of Journal: Mol Biol Rep

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Abbravation: Molecular Biology Reports

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Springer Netherlands

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DOI

10.1016/0005-2787(74)90233-0

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1573-4978

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The a1/a2 polymorphism of the glycoprotein IIIa ge

Authors: Jovana NikolajevićStarčević Daniel Petrovič
Publish Date: 2012/11/27
Volume: 40, Issue: 3, Pages: 2077-2081
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Abstract

A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of coronary artery disease CAD and myocardial infarction MI The aim of this study was to investigate an association between the PlA1/A2 polymorphism of the glycoprotein IIIa gene and the risk of MI in Caucasians with type 2 diabetes 549 Caucasians with type 2 diabetes were enrolled in the cross sectional retrospective case–control study 224 patients with MI and 325 diabetic subjects without CAD Blood biochemical analysis was performed The polymerase chain reaction with restriction fragment length polymorphism was used for genetic analysis Patients with MI were older 62 ± 118 vs 585 ± 116 years P  0001 and had a longer duration of type 2 diabetes 176 ± 89 vs 151 ± 92 P = 001 compared to the diabetics without CAD A significant difference in distribution of the A2A2 genotype of glycoprotein IIIa was not found between 224 diabetic patients with MI in comparison to 325 diabetics without CAD 116 vs 141  ns The diabetes duration and male sex were independent factors for the development of MI whereas the PlA1/A2 polymorphism of glycoprotein IIIa was not To conclude The A2A2 genotype of the glycoprotein IIIa polymorphism was not associated with MI risk in Caucasians with type 2 diabetes

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