Authors: Zhan Gao HongJuan Fu JuJun Xue ZhiXuan Wu LiBo Zhao
Publish Date: 2014/03/05
Volume: 41, Issue: 7, Pages: 4463-4474
Abstract
We conducted this metaanalysis of relevant case–control studies to investigate the relationships between genetic polymorphisms in VDR ESR1 and ESR2 genes to the susceptibility of Parkinson’s disease PD A search on electronic databases without any language restrictions was conducted MEDLINE 1966–2013 the Cochrane Library Database Issue 12 2013 EMBASE 1980–2013 CINAHL 1982–2013 Web of Science 1945–2013 and the Chinese Biomedical Database 1982–2013 Metaanalysis was performed using the STATA statistical software Crude odds ratio OR with their 95 confidence interval 95 CI was calculated Fourteen case–control studies with a total of 3689 PD patients and 4627 healthy subjects were included in our metaanalysis The results of our metaanalysis demonstrated that the VDR genetic polymorphisms might be closely related to increased risks of PD allele model OR = 118 95 CI 109–129 P 0001 dominant model OR = 137 95 CI 116–163 P 0001 respectively especially for the polymorphisms rs7976091 and rs10735810 Our findings also illustrated that ESR1 genetic polymorphisms might increase the risk of PD allele model OR = 156 95 CI 117–207 P = 0002 recessive model OR = 193 95 CI 133–280 P 0001 homozygous model OR = 135 95 CI 102–179 P = 0038 heterozygous model OR = 204 95 CI 136–307 P = 0001 respectively especially for the polymorphisms rs2234693 and rs9340799 Furthermore we found significant correlations of ESR2 genetic polymorphisms with the risk of PD allele model OR = 178 95 CI 119–267 P = 0005 recessive model OR = 193 95 CI 115–327 P = 0014 homozygous model OR = 177 95 CI 109–289 P = 0022 heterozygous model OR = 188 95 CI 108–327 P = 0025 respectively especially for the rs1256049 polymorphism Our metaanalysis suggests that genetic polymorphisms in VDR ESR1 and ESR2 genes may contribute to increased risks for PD
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