Authors: Francisco de Assis Caldas Pereira Clarissa Araújo Silva Gurgel Eduardo Antônio Gonçalves Ramos Manuela Torres Andion Vidal Antônio Luiz Barbosa Pinheiro Vladimir Jurisic Caroline Brandi Schlaepfer Sales Patrícia Ramos Cury Jean Nunes dos Santos
Publish Date: 2011/11/30
Volume: 33, Issue: 2, Pages: 455-461
Abstract
The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors Fortyfive cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase and differences between groups were statistically evaluated Mast cells were present in 96 of odontogenic tumors Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands with or without squamous metaplasia The odontogenic mixoma showed few mast cells In odontogenic tumors with a cystic structure the mast cells were distributed throughout all areas of the lesions mainly in keratocystic odontogenic tumor In addition the total density of mast cells between all odontogenic tumors showed no significant difference p 005 A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor p 001 and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma p 005 Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome p = 003 Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors
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