Authors: Binjie Liu Ting Shen
Publish Date: 2013/09/20
Volume: 35, Issue: 1, Pages: 507-512
Abstract
Previous studies regarding the association between Xray repair crosscomplementing group 1 XRCC1 Arg399Gln polymorphism and oral cancer risk were contradictory We performed a metaanalysis to derive a more precise estimation of the association The PubMed and Web of Science were searched for eligible studies Odds ratio OR with its 95 confidence interval 95 CIs was used to assess the strength of the association Nine individual studies with a total of 3244 subjects were finally included into the metaanalysis Overall there was no association between XRCC1 Arg399Gln polymorphism and oral cancer risk under all genetic models Gln versus Arg OR = 109 95 CI 086–137 P = 046 GlnGln versus ArgArg OR = 111 95 CI 069–179 P = 066 GlnGln versus ArgArg/ArgGln OR = 104 95 CI 068–161 P = 084 and GlnGln/ArgGln versus ArgArg OR = 113 95 CI 088–144 P = 034 After excluding studies on oral leukoplakia there was still no association between XRCC1 Arg399Gln polymorphism and oral cancer risk under all genetic models Subgroup analysis by ethnicity suggested that there was no association between XRCC1 Arg399Gln polymorphism and oral cancer risk in both Asians and Caucasians In conclusion the data from the metaanalysis suggests that XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk
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