Authors: Ying Li Xi Wei Sheng zhang Jin Zhang
Publish Date: 2015/06/09
Volume: 36, Issue: 11, Pages: 8755-8760
Abstract
The aim of this study was to investigate the role of ultrasonographic microvascular imaging in the evaluation of prognosis of patients with invasive breast cancer treated by adjuvant therapies A total of 121 patients with invasive breast cancer underwent ultrasonographic contrastenhanced imaging vascular endothelial growth factor VEGF staining and microvessel density MVD counts The parameters of microvascular imaging and the expression of VEGF and MVD in primary breast cancer were calculated The correlation between these factors and the overall and progressionfree survival rate were analyzed using the KaplanMeier method Among 121 cases the positive VEGF cases were 75 and negative ones were 46 The cut point of 523 was calculated by the regressive curve for MVD counts The data showed the mean intensity MI was positively associated with both the MVD counts r = 51 p 001 and VEGF expression r = 35 p 001 For the prognosis of patients high VEGF expression and MVD counts were associated with reduced progressive and survival times PFS p = 032 and p = 034 OS p = 041 and p = 038 respectively The correlation between parameters of microvascular imaging VEGF expressive status and the MVD counts were established The cut point of mean intensity MI = 40 was used to investigate as an independent predictor for PFS p = 021 and OS p = 025 respectively due to a strong correlation between MVD counts and VEGF expression in patients with invasive breast cancer The microvascular imaging could be a visual and helpful tool to predict the prognosis of patients with invasive breast cancer treated by adjuvant therapies
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