Authors: Jun Gu Jie Chen Jian Feng Yifei Liu Qun Xue Guoxin Mao Ling Gai Xiaoning Lu Rui Zhang Jialin Cheng Yanxia Hu Mengting Shao Hong Shen Jianan Huang
Publish Date: 2016/01/06
Volume: 37, Issue: 7, Pages: 8681-8689
Abstract
Nonsmall cell lung cancer NSCLC is the major cause of cancerrelated lethality among human cancer patients globally and the poor prognosis of this cancer is mainly explained by metastasis so it is essential to find out the molecule mechanisms and a novel therapeutic for NSCLC A disintegrin and metalloprotease with thrombospondin motif 5 ADAMTS5 belongs to the protease family It has been reported to participate in tumor migration and invasion In this study we showed that the expression of ADAMTS5 was higher in lung cancer tissues by Western blot The immunohistochemistry analysis was performed in 140 NSCLC cases and the result indicated that ADAMTS5 was significantly associated with clinical pathologic variables The Kaplan–Meier curve showed that the high expression of ADAMTS5 was related to poor prognosis of lung cancer patients Wound healing assays and transwell migration assays revealed that the high expression of ADAMTS5 promoted the migration and invasion of NSCLC In a word our findings suggest that ADAMTS5 can regulate the migration and invasion of NSCLC and it may be a useful target of therapy in NSCLC
Keywords: