Authors: Gang Cao Weihua Dong Xiaoxi Meng Hongchao Liu Huaqiang Liao Shiyuan Liu
Publish Date: 2015/01/22
Volume: 36, Issue: 6, Pages: 4453-4459
Abstract
MicroRNAs miRNAs are critical for cancer development and progression Elucidating the underlying mechanism of miRNAs in carcinogenesis may lead to novel diagnostic and therapeutic strategies for malignancy In this study we found that miR511 expression was markedly downregulated in hepatocellular carcinoma HCC cell lines and tissues Phosphoinositide3kinase regulatory subunit 3 PIK3R3 was identified as a direct target of miR511 and miR511 expression inversely correlated with PIK3R3 mRNA expression in clinical HCC tissues We further demonstrated that miR511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression Investigations of possible mechanisms underlying these results revealed that miR511 inhibited the phosphorylation of AKT and mTOR which are key participants in the AKT/mTOR pathway Taken together our findings provide new insights into tumor suppression by miR511 by negatively regulating the PIK3R3/AKT/mTOR signaling pathway
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