Authors: Su Chen Jian Jiao Dongjie Jiang Zongmiao Wan Lei Li Ke Li Leqin Xu Zhenhua Zhou Wei Xu Jianru Xiao
Publish Date: 2015/03/06
Volume: 36, Issue: 8, Pages: 5881-5890
Abstract
Both intratumor macrophage and Tbox transcription factor Brachyury T have been proved to play important roles in tumor progression and metastasis However it is still unknown whether T could regulate the infiltration of macrophages Here we report that the Brachyury expression in human lung tumors was inversely correlated with the infiltration of macrophages Brachyury suppressed the capability of human lung cancer cells to attract macrophages Using PCR array we found that Brachyury inhibited expression of several chemokines including CCL2 CCL4 and CXCL10 Accordingly knockdown of CCL2 and CCL4 in lung cancer cells suppressed macrophage invasion under coculture conditions Furthermore we found that Brachyury expression was inversely correlated with CCL2 and CCL4 expression in human lung tumors Taken together our findings shed light on the novel role of Brachyury in regulation of macrophage infiltration
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