Authors: Chibo Liu Haibao Wang
Publish Date: 2013/04/05
Volume: 34, Issue: 4, Pages: 2249-2254
Abstract
The Xray repair crosscomplementing group 3 XRCC3 gene has been suggested to play an important role in the pathogenesis of hepatocellular carcinoma HCC However the results have been inconsistent In this study we performed a metaanalysis to clarify the association of XRCC3 Thr241Met variant with HCC The published literature from PubMed Chinese National Knowledge Infrastructure and Wan Fang data was retrieved Pooled odds ratio OR with 95 confidence interval CI was calculated using fixed or random effects model A total of five studies 1531 HCC cancer cases and 1952 controls for XRCC3 Thr241Met variant were included in the metaanalysis The metaanalysis showed that XRCC3 Thr241Met variant was associated with HCC risk under homogeneous codominant model OR = 399 95 CI = 174–913 and recessive model OR = 522 95 CI = 365–748 but not under heterogeneous codominant model OR = 118 95 CI = 068–205 and dominant model OR = 137 95 CI = 073–257 Subgroup analysis by ethnicity suggested that XRCC3 Thr241Met variant was associated with HCC risk in Chinese population but not in Pakistani population The present metaanalysis supported the positive association of XRCC3 Thr241Met variant with HCC in the Chinese Further largescale studies with the consideration for gene–gene/gene–environment interactions should be conducted to investigate the association
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