Authors: Jie Kang XianZhao Deng YouBen Fan Bo Wu
Publish Date: 2014/04/24
Volume: 35, Issue: 7, Pages: 7085-7096
Abstract
We conducted the metaanalysis of all relevant case–control studies aiming to evaluate the relationships of common polymorphisms in forkhead box E1 FOXE1 and ataxia telangiectasia mutated ATM genes to the risk of papillary thyroid carcinoma PTC A range of electronic databases were searched without language restrictions Web of Science 1945 ~ 2013 the Cochrane Library Database Issue 12 2013 PubMed 1966 ~ 2013 EMBASE 1980 ~ 2013 CINAHL 1982 ~ 2013 and the Chinese Biomedical Database CBM 1982 ~ 2013 This metaanalysis was conducted using the STATA 120 software Crude odds ratio OR with their 95 confidence interval CI were calculated Eight case–control studies with 2085 PTC patients and 10341 healthy controls were included Fourteen common polymorphisms were evaluated including rs3758249 A G rs907577 G A rs1867277 G A rs3021526 C T rs1443434 G T rs907580 G A rs965513 A G rs944289 C T and rs189037 G A polymorphisms in the FOXE1 gene and rs373759 G A rs4988099 A G rs1801516 G A rs664677 T C and rs609429 G C polymorphisms in the ATM gene Our results demonstrated that the FOXE genetic polymorphisms might be closely related to an increased risk of developing PTC under five genetic models all P 0005 especially for rs3758249 rs907577 rs1867277 rs3021526 rs1443434 rs907580 rs704839 rs894673 and rs10119760 polymorphisms Nevertheless no positive associations were found between the ATM genetic polymorphisms and the development of PTC all P 005 The current metaanalysis provided evidence that FOXE1 genetic polymorphisms may contribute to increased PTC risk especially for rs3758249 rs907577 rs1867277 rs3021526 rs1443434 rs907580 rs704839 rs894673 and rs10119760 polymorphisms However the ATM genetic polymorphisms may not be important dominants of susceptibility to PTC
Keywords: