Authors: Hui Kong Yanli Wang Xiaoning Zeng Zailiang Wang Hong Wang Weiping Xie
Publish Date: 2015/04/25
Volume: 36, Issue: 10, Pages: 7501-7513
Abstract
As pivotal elements involved in inflammation inflammasomes represent a group of multiprotein complexes triggering the maturation of proinflammatory cytokine interleukin IL1β and IL18 Although the importance of the inflammasomes in inflammatory diseases is well appreciated a precise characterization of their expressions in lung cancer remains obscure This study aimed to determine the expressions of inflammasomes in various lung cancer cell lines and tissues to understand their potential roles in lung cancer Our findings showed that inflammasome components were markedly upregulated in lung cancer and elicited the maturation of IL1β and IL18 In addition enormous variations in subtypes and levels of inflammasomes were detected in lung cancers depending on their histological type and grading invasion ability as well as chemoresistance Generally AIM2 inflammasome was overexpressed in nonsmall cell lung cancer NSCLC while NLRP3 inflammasome was upregulated in lung adenocarcinoma ADC and small cell lung cancer SCLC The highmetastatic or cisplatinsensitive NSCLC cells expressed more inflammasome components and products than their counterpart lowmetastatic or cisplatinresistant NSCLC cells respectively In resected lung cancer tissues highgrade ADC expressed more inflammasome components and products than lowgrade ADC Together these findings suggest that inflammasomes may be crucial biomarkers for lung cancer as well as potential modulators of the biological behaviors of lung cancer Further pharmacotherapeutics targeting inflammasomes might be novel adjuvant therapy strategies for lung cancer
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