Authors: Samia Shabnaz Maizbha Uddin Ahmed Md Siddiqul Islam Md Reazul Islam Mir Md Abdullah AlMamun Mohammad Safiqul Islam Abul Hasnat
Publish Date: 2015/12/14
Volume: 37, Issue: 6, Pages: 7229-7237
Abstract
Pharmacogenomic studies play a significant role in understanding the risk of breast cancer where genetic abnormalities are implicated as the etiology of cancer Various polymorphisms of tumor suppressor gene TP53 and Ecadherin CDH1 have been found to be associated with increased breast cancer risk worldwide This study aimed to analyze the contribution of TP53 and CDH1 gene anomalies in breast cancer risk in the Bangladeshi breast cancer patients For risk determination 310 patients with breast cancer and 250 controls from Bangladeshi women were recruited who are matched up with age and use of contraceptives with patients Genetic polymorphisms were detected by using polymerase chain reaction restriction fragment length polymorphism A significant association was found between TP53Arg72Pro rs1042522 and CDH1 160 C/A rs16260 polymorphisms and breast cancer risk In case of P53rs1042522 polymorphism Arg/Pro P = 00053 odds ratio OR = 169 and Pro/Pro P = 0018 OR = 183 genotypes were associated with increased risk of breast cancer in comparison to the Arg/Arg genotype Arg/Pro + Pro/Pro genotype and Pro allele also increased the risk of breast cancer P = 0002 OR = 173 P = 0004 OR = 143 respectively In case of CDH1rs16260 polymorphism C/A heterozygote and combined C/A + A/A genotypes were found to be strongly associated P = 0005 OR = 167 P = 00037 OR = 168 with increased risk of breast cancer The variant A allele also increased the breast cancer risk P = 00058 OR = 152 The present study demonstrates that P53Arg72Pro and CDH1rs16260 polymorphisms are associated with elevated breast cancer risk in the Bangladeshi populationThe authors are thankful to all the staffs nurses and physicians of Ahsania Mission Cancer and General Hospital Dhaka Medical College Hospital and Bangabandhu Sheikh Mujib Medical University BSMMU Dhaka Bangladesh and the participants of this study The authors are also thankful to all the staffs and faculty members of the Department of Clinical Pharmacy and Pharmacology University of Dhaka Bangladesh for their partial financial support for this study The authors have no other relevant affiliation or financial involvement with any organization
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